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KMID : 0616120080390020080
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Korean Journal of Pharmacognosy
2008 Volume.39 No. 2 p.80 ~ p.85
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The Effect of Herbal Formulation KH-305 Mainly consisted of Rubus Coreanus on Benign Prostatic Hyperplasia-Induced Rat
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Kim Sung-Dae
Sohn Dong-Wan
Kim Sae-Woong
Cho Yong-Hyun
Lee Byung-Hee
Lee Seung-Min
Kim Jeong-Ok
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Abstract
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Benign prostatic hyperplasia (BPH) is one of the common diseases in elderly men. Recently, the old-aged population has increased, with the interest in the clinical importance of BPH ever growing. This study is designed to investigate the effects of KH-305 on BPH induced rat. The herb formulation KH-305 is consisted of Rubus coreanus, Cornus officinalis and Cuscuta chinensis. An experimental prostatic hyperplasia was induced in male rats by the administration of testosterone propionate, 3 mg/kg SC, for 2 months. The rats were divided into 3 experimental groups: the control, BPH-induced, oral KH-305 ingestion group. After 2 months, the prostates were removed, and analyzed for their prostatic weight and histological examination. The prostate weights were measured in each group, and found to be 820±38mg, 3140±26mg, 1880±21mg in the control, BPH-induced, and oral KH-305 ingestion group, respectively. The BPH induced group showed statistically significant increases in their prostatic weights compared with control group(p<0.05) but oral KH-305 ingestion group showed more significant decreases than BPH-induced group statically(p<0.05). Histologically injected testosterone lead to prostatic hyperplasia in rats, but oral KH-305 ingestion decreased this change. These results suggest that KH-305 may be effective in treatment of BPH, and complementary medicine of BPH.
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KEYWORD
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BPH (benign prostatic hyperplasia), rubus coreanus, rat model
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